The Established Status Epilepticus Treatment Trial (ESETT) is a multicenter, randomized, double-blind, comparative effectiveness study of fos-phenytoin, levetiracetam, and valproic acid in subjects with benzodiazepine-refractory status epilepticus. Patients will be recruited by two national emergency research networks:  Neurology Emergency Treatment Trials (NETT) network and Pediatric Emergency Care and Applied Research Network (PECARN).  Each network has successfully undertaken a Status Epilepticus treatment trial under exception from informed consent (EFIC) rules

 

  1. See the Official ESETT Webpage -
  2. What exactly is the Neurological Emergency Treatment Trials?
  3. Check out the ESETT Study Synopsis
  4. Learn more about Emergency Research & Exception From Informed Consent
  5. Read the actual FDA Guidance on EFIC - 21 CFR 50.24
  6. CLICK HERE to go directly to the ESETT EFIC SURVEY web page
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